What are Canker Sores ?

Canker sores are small ulcer craters in the lining of the mouth that are frequently painful and sensitive, medically termed as aphthous stomatitis, ulcerative stomatitis, or aphthae are mostly self healing and can recur, can make eating and talking uncomfortable. Canker sores appear as a whitish round area with a red border. Canker sores usually occur on the moveable parts of mouth, such as tongue, inside lining of the lips and cheeks. They are a common form of mouth ulcer. A canker sore is benign (not harmful). An average canker sore is about one- quarter of an inch in size to more than an inch in severe cases. Severe form of the sore may leave scars. Often several canker sores appear at the same time and may be grouped in clusters. Canker sores are not infectious. Canker sores may also occur at the site of a bite when the tongue or cheek is bitten.

What are some symptoms of Canker Sores ?
 
A canker sore is an open wound, and being inside the mouth, cannot be covered so the exposed nerve endings are irritated causing extreme pain. This also leaves the canker sore vulnerable to infection by bacteria creating even more pain. Anyone can get canker sores, but women people in their teens and 20s get them more often. Therefore they occur more often in women than in men. They may occur at any age, but usually first appear at ages between 10-40. They begin as:


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  • Initial symptom is a tingling or mildly itching sensation in the area where the sore will appear.

  • After one to several days small oval or round swellings appear that burst within a day.

  • Ruptured sores are then covered with a thin white or yellow membrane edged by a red halo.

  • Main symptom is pain, canker sores can be very painful, especially if they are touched repeatedly eg, by the tongue.

  • Usually one quarter inch in diameter and 1-2 mm wide.

  • Occur on the non-keratinized mucosa inside the mouth but not on the hard roof of the mouth.

  • Generally heal within 4-14 days.

  • They may leave scars.

  • Recur monthly or several times per year.

  • In severe attacks there may be fever, physical sluggishness and swollen lymph nodes.

Two Types of canker sores

Simple canker sores: These may appear 3-4 times a year. They account for about 70% of all cases, may last upto a week and heal with little or no scarring.

Complex canker sores: These are less common and occur more often in people who have previously had them. They are greater than 1 cm in size, take longer time to heal (upto 3 weeks or longer) and leave scars after they heal.

 

Although the vast majority of canker sore cases are associated with no underlying illness, in a small percentage of cases, canker sores are indicative of a bodily (systemic) disorder. People with Behcet's Disease, for instance, will often have canker sores ( mouth ulcers ) in addition to genital lesions, eye lesions, and general skin afflictions. HIV infected patients may also develop canker sore like ulcers. In the small percentage of cases where an underlying condition may be suspected, a careful medical history and examination by a physician will be able to indicate whether canker sores in a particular patient are associated with an underlying disorder.

Canker sores are sometimes confused with cold sores, although they are not the same. Cold sores are caused by herpes simplex virus, also called fever blister. They are a group of painful fluid filled blisters. Unlike canker sores, cold sores are contagious, being caused by a virus. Also cold sores typically appear outside the mouth- usually under the nose, around the lips, or under the chin, while canker sores occur inside the mouth.

 

Causes of Canker Sores ?

 

Exact cause of most canker sores is unknown. Current theories on the causes of canker sores have focused on the following:

  • Stress/trauma or tissue injury may cause eruption of canker sores.

  • Nutritional problems such as deficiency of vitamin B12, zinc, folic acid or iron.

  • Gastrointestinal tract disease such as Celiac disease and Crohn's disease.

  • Food allergies

  • Infection with AIDS virus also have been associated with canker sores.

  • Acidic foods such as tomatoes, citrus fruits, and other tangy food items may help to encourage development of canker sores.

  • Canker sores tend to run in the families and may be an inherited condition.

  • Recent research suggests that canker sores may be caused by the body's own immune system attacking the cells lining the inside of the mouth(autoimmune disorders). Examples of autoimmune disorders are systemic lupus erythematosus, Bechet’s syndrome.

  • Smoking.

  • Female sex hormones may also apparently play a role in causing canker sores. Many women experience bouts of the sores only during certain phases of their menstrual cycles.Additionally, most women experience improvement or remission of their canker sores during pregnancy.

Prevention of Canker Sores

Canker sores can recur, but one can reduce their frequency by addressing factors that seem to trigger canker sores.

  • Trauma to the inside of the mouth can trigger an outbreak of canker sores. This trauma includes overzealous tooth brushing, biting cheek or tongue, and scraping the inside of the mouth with hard or sharp foods (like hard pretzels). It is therefore advisable to stop brushing so hard, cut down on eating foods like potato chips, hard pretzels, cut apples, and hard candies which might nick, abrade, or otherwise traumatize the oral tissue.

  • Stress is another factor capable of triggering canker sores. It is advisable to those patients susceptible to canker sores to try to reduce the stress in their lives.

Research suggests that reactions to certain food products may be responsible for many cases of canker sores. Among the foods that may cause canker sores in certain people are: nuts, peanut butter, sea food, wheat products, chocolate, and milk.

One of the most exciting advances has been the establishment of the link between canker sores and an ingredient common to almost all toothpastes. The additive SLS or sodium lauryl sulfate may be a culprit in canker sore formation. The thought is that SLS may, in susceptible individuals, cause microscopic trauma or membrane disruption to the skin cells in the mouth. This along with trauma or actions of the immune system may lead to canker sore formation. Many of the patients have benefited greatly from using toothpastes which don't contain SLS.

  • Have any irregular dental surfaces repaired.

  • Avoid acidic foods that irritate the mouth.

Possible Treatment of Canker Sores

Often treatment isn’t necessary and the canker sore heals on its own. It may be required if the sores are large, painful or persistent. Treatment helps ease the pain and may help reduce the amount of time it takes for the ulcers to go away. 

  • Corticosteroid Rinses and Gels: Often prescribed by a dentist or physician for severe or painful cases, these medications have proven extremely effective.Eg, triamcinolone acetonide, steroid (non-alcoholic) gel of lidex is commonly prescribed. Commonly they are to be applied to the lesions 3 times daily.More recently amlexanox is prescribed due to its anti-inflammatory and anti-allergic effects. 

  • Analgesic (Pain Relieving) and Protective Ointments and Gels: These are pain relieving medications which can be purchased at your local drug store. These include compounds such as Zilactin or Oragel. Many of these compounds, after being applied, dry forming a protective cover over the sensitive ulcerations. 

  • Anti-microbial Mouthwashes: Surprisingly the use of anti-microbial mouthwashes has provided effective relief for many. Canker Sores are not caused by a bacteria or virus so the mechanisms by which these anti-microbial mouthwashes work remains unclear. Commonly prescribed are anti-microbial mouthwashes containing the active ingredient chlorhexidine gluconate . Eg, tetracycline suspensions (Achromycin, Panmycin) used as mouth wash can relief pain and accelerate healing.

  • The doctor may prescribe iron, folic acid, or vitamin B12 supplements if canker sore results from a deficiency of these vitamins.

  • Some women may develop new attacks or worsening of canker sores during their premenstrual phase. An estrogen dominant oral contraceptive may help.

  • Recently a new prescription drug debacterol is available which when applied to the ulcer helps to seal it and allow it to heal.

 

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Article Contributed By: Shaonli Dasgupta

 

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